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157th Homecoming Anniversary Group

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Carlos Abad Molinero
Carlos Abad Molinero

Clinical Chemistry Bishop Case S

Clinical Chemistry Bishop Case S

Clinical chemistry is the branch of laboratory medicine that deals with the measurement and interpretation of chemical components in blood and other body fluids. It covers a wide range of topics, such as metabolism, endocrinology, toxicology, immunology, and organ function. Clinical chemistry tests can help diagnose diseases, monitor treatment, and assess health status. One of the most popular and comprehensive textbooks on clinical chemistry is Clinical Chemistry: Principles, Techniques, and Correlations by Michael L. Bishop, Edward P. Fody, Larry E. Schoeff, and others . This book provides a clear and student-friendly introduction to the principles, techniques, and clinical applications of clinical chemistry.


One of the features of this book is the inclusion of case studies that illustrate the clinical relevance and interpretation of laboratory data. Each case study presents a patient's history, physical examination, laboratory results, diagnosis, and discussion. The case studies are organized by chapters that correspond to different areas of clinical chemistry, such as basic principles, analytic procedures, endocrinology, organ systems, and specialty areas. The case studies help students develop their problem-solving and critical thinking skills, as well as their understanding of the correlation between laboratory results and disease states.

One example of a case study from this book is Case S, which is found in Chapter 18: Liver Function . This case study involves a 45-year-old man who presents with jaundice, dark urine, pale stools, pruritus, and fatigue. He has a history of alcohol abuse and hepatitis B infection. His laboratory results show elevated levels of bilirubin, alkaline phosphatase, gamma-glutamyl transferase, aspartate aminotransferase, and alanine aminotransferase. His serum albumin and prothrombin time are normal. His hepatitis B surface antigen is positive. His diagnosis is chronic hepatitis B with alcoholic liver disease. The discussion explains the pathophysiology and clinical significance of the laboratory findings, as well as the differential diagnosis and treatment options for the patient.

This case study demonstrates how clinical chemistry tests can provide valuable information about the function and damage of the liver, which is a vital organ that performs many metabolic and synthetic functions. It also shows how clinical chemistry tests can help differentiate between various causes of liver disease, such as viral infection, alcohol abuse, autoimmune disorder, drug toxicity, or cancer. By applying the principles and techniques of clinical chemistry to real-life scenarios, students can enhance their learning experience and prepare for their future careers in laboratory medicine.


  • Bishop ML, Fody EP, Schoeff LE. Clinical Chemistry: Principles, Techniques, and Correlations. 8th ed. Philadelphia: Wolters Kluwer; 2018.

  • Bishop ML, Fody EP, Van Siclen C, Mistler JM. Clinical Chemistry: Principles, Techniques, and Correlations. 9th ed. Burlington: Jones & Bartlett Learning; 2022.


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